1. Division of Pharmaceutical Chemistry, Faculty of Pharmacy, P.O. Box 56, FI-00014 University of Helsinki, Finland, Laboratory of Analytical Chemistry, Department of Chemistry, P.O. Box 55, FI-00014 University of Helsinki, Finland, Micro and Nanosciences Laboratory, Helsinki University of Technology, P.O. Box 3500, FI-02015 TKK, Finland, and Drug Discovery and Development Technology Center, Faculty of Pharmacy, P.O. Box 56, FI-00014 University of Helsinki, Finland