A Brain-Permeable Small Molecule Reduces Neuronal Cholesterol by Inhibiting Activity of Sirtuin 2 Deacetylase-Reference-Cited by-同舟云学术

A Brain-Permeable Small Molecule Reduces Neuronal Cholesterol by Inhibiting Activity of Sirtuin 2 Deacetylase

Published:2011-03-09 Issue:6 Volume:6 Page:540-546
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Taylor David M.¹,Balabadra Uma²,Xiang Zhongmin³,Woodman Ben⁴,Meade Sarah³,Amore Allison³,Maxwell Michele M.³⁵,Reeves Steven³,Bates Gillian P.⁴,Luthi-Carter Ruth¹,Lowden Philip A. S.²,Kazantsev Aleksey G.³⁵

Affiliation:

1. Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland

2. Department of Biological Sciences, Birkbeck, University of London, Malet Street, London WC1E 7HX, U.K.

3. MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, Massachusetts 02129, United States

4. Department of Medical and Molecular Genetics, King’s College London, Eighth Floor Tower Wing, Guy’s Hospital, Great Maze Pond, London SE1 9RT, U.K.

5. Harvard Medical School, Boston, Massachusetts 02129, United States

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/cb100376q

Reference18 articles.

1. Biological and Potential Therapeutic Roles of Sirtuin Deacetylases

2. The Human Sir2 Ortholog, SIRT2, Is an NAD+-Dependent Tubulin Deacetylase

3. Mitotic Regulation of SIRT2 by Cyclin-dependent Kinase 1-dependent Phosphorylation

4. The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility

5. Genome-wide Analysis of Chromatin Regulation by Cocaine Reveals a Role for Sirtuins

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