Discovery of (R)-1-(7-Chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): A Temperature-Neutral Transient Receptor Potential Vanilloid-1 (TRPV1) Antagonist with Analgesic Efficacy
Author:
Affiliation:
1. Research & Development, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States
Funder
AbbVie
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm500916t
Reference55 articles.
1. TRP Channels and Pain
2. The capsaicin receptor: a heat-activated ion channel in the pain pathway
3. Vanilloid Receptor TRPV1 Antagonists as the Next Generation of Painkillers. Are We Putting the Cart before the Horse?
4. TRPV1: On the Road to Pain Relief
5. An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors
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