Synthesis and Evaluation of Novologues as C-Terminal Hsp90 Inhibitors with Cytoprotective Activity against Sensory Neuron Glucotoxicity-Reference-Cited by-同舟云学术

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Synthesis and Evaluation of Novologues as C-Terminal Hsp90 Inhibitors with Cytoprotective Activity against Sensory Neuron Glucotoxicity

Published:2012-06-15 Issue:12 Volume:55 Page:5797-5812
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kusuma Bhaskar Reddy¹,Zhang Liang²,Sundstrom Teather¹,Peterson Laura B.¹,Dobrowsky Rick T.²,Blagg Brian S. J.¹

Affiliation:

1. Department of Medicinal Chemistry, The University of Kansas, 1251 Wescoe Hall Drive, Malott Hall 4070, Lawrence, Kansas 66045-7563, United States

2. Pharmacology and Toxicology Department, The University of Kansas, Lawrence, Kansas 66045, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300544c

Reference30 articles.

1. Painful Diabetic Neuropathy: Epidemiology, Natural History, Early Diagnosis, and Treatment Options

2. Glucose neurotoxicity

3. Hsp70 chaperones: Cellular functions and molecular mechanism

4. To fold or not to fold: modulation and consequences of Hsp90 inhibition

5. Novobiocin: Redesigning a DNA Gyrase Inhibitor for Selective Inhibition of Hsp90

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