Kynurenine 3-Monooxygenase from Pseudomonas fluorescens: Substrate-like Inhibitors both Stimulate Flavin Reduction and Stabilize the Flavin−Peroxo Intermediate yet Result in the Production of Hydrogen Peroxide-Reference-Cited by-同舟云学术

Kynurenine 3-Monooxygenase from Pseudomonas fluorescens: Substrate-like Inhibitors both Stimulate Flavin Reduction and Stabilize the Flavin−Peroxo Intermediate yet Result in the Production of Hydrogen Peroxide

Published:2008-10-28 Issue:47 Volume:47 Page:12420-12433
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Crozier-Reabe Karen R.¹,Phillips Robert S.¹,Moran Graham R.¹

Affiliation:

1. Department of Chemistry and Biochemistry, University of Wisconsin, 3210 North Cramer Street, Milwaukee, Wisconsin 53211-3029, and Departments of Chemistry and of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602-2556

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi8010434

Reference54 articles.

1. Chemistry and neurochemistry of the kynurenine pathway of tryptophan metabolism

2. Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenate and have sedative and anticonvulsant activities

3. Studies on the Neuroprotective Action of Kynurenine Mono-Oxygenase Inhibitors in Post-Ischemic Brain Damage

4. A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease

5. L-kynurenine: metabolism and mechanism of neuroprotection

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