Influence of Glutathione and Glutathione S-transferases on DNA Interstrand Cross-Link Formation by 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine, the Active Anticancer Moiety Generated by Laromustine-Reference-Cited by-同舟云学术

Influence of Glutathione and Glutathione S-transferases on DNA Interstrand Cross-Link Formation by 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine, the Active Anticancer Moiety Generated by Laromustine

Published:2014-07-17 Issue:8 Volume:27 Page:1440-1449
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Penketh Philip G.¹,Patridge Eric¹,Shyam Krishnamurthy¹,Baumann Raymond P.¹,Zhu Rui¹,Ishiguro Kimiko¹,Sartorelli Alan C.¹

Affiliation:

1. Department of Pharmacology and Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut 06520, United States

Funder

National Cancer Institute

U.S. Public Health Service

National Foundation for Cancer Research

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx500197t

Reference46 articles.

1. 1,2-Bis(sulfonyl)hydrazines. 3. Effects of structural modification on antineoplastic activity

2. Antitumor 2-(Aminocarbonyl)-1,2-bis(methylsulfonyl)-1-(2-chloroethyl)- hydrazines

3. Studies on the Mechanism of Decomposition and Structural Factors Affecting the Aqueous Stability of 1,2-Bis(sulfonyl)-1-alkylhydrazines

4. Synthesis and evaluation of 1-acyl-1,2-bis(methylsulfonyl)-2-(2-chloroethyl)hydrazines as antineoplastic agents

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