Crystal Structure of β-Hexosaminidase B in Complex with Pyrimethamine, a Potential Pharmacological Chaperone
Author:
Affiliation:
1. Department of Biochemistry, 4-29 Medical Sciences Building, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada
2. Research Institute, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm101443u
Reference36 articles.
1. Crystal Structure of Human β-Hexosaminidase B: Understanding the Molecular Basis of Sandhoff and Tay–Sachs Disease
2. Physiological Substrates for Human Lysosomal β-Hexosaminidase S
3. Liberation of N-acetylglucosamine-6-sulfate by human beta-N-acetylhexosaminidase A.
4. Crystallographic Evidence for Substrate-assisted Catalysis in a Bacterial β-Hexosaminidase
5. The X-ray Crystal Structure of Human β-Hexosaminidase B Provides New Insights into Sandhoff Disease
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