Structural Investigation of the 7-Chloro-3-hydroxy-1H-quinazoline-2,4-dione Scaffold to Obtain AMPA and Kainate Receptor Selective Antagonists. Synthesis, Pharmacological, and Molecular Modeling Studies-Reference-Cited by-同舟云学术

Structural Investigation of the 7-Chloro-3-hydroxy-1H-quinazoline-2,4-dione Scaffold to Obtain AMPA and Kainate Receptor Selective Antagonists. Synthesis, Pharmacological, and Molecular Modeling Studies

Published:2006-09-12 Issue:20 Volume:49 Page:6015-6026
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Colotta Vittoria¹,Catarzi Daniela¹,Varano Flavia¹,Lenzi Ombretta¹,Filacchioni Guido¹,Costagli Chiara¹,Galli Alessandro¹,Ghelardini Carla¹,Galeotti Nicoletta¹,Gratteri Paola¹,Sgrignani Jacopo¹,Deflorian Francesca¹,Moro Stefano¹

Affiliation:

1. Dipartimento di Scienze Farmaceutiche, Laboratorio di Progettazione, Sintesi e Studio di Eterocicli Biologicamente Attivi, Polo Scientifico, Università degli Studi di Firenze, Via Ugo Schiff, 6, 50019 Sesto Fiorentino, (FI), Italy, Dipartimento di Farmacologia Preclinica e Clinica, Università degli Studi di Firenze, Viale Pieraccini, 6, 50134 Firenze, Italy, Laboratorio di Molecular Modeling, Cheminformatics, and QSAR, Dipartimento di Scienze Farmaceutiche, Laboratorio di Progettazione, Sintesi e Studio...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0604880

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