A Personal View of Molecular Technology and How It Has Changed Biology
Author:
Affiliation:
1. President and Director, Institute for Systems Biology, Seattle, Washington 98103
Publisher
American Chemical Society (ACS)
Subject
General Chemistry,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/pr020299f
Reference59 articles.
1. An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH
2. Two mRNAs with different 3′ ends encode membrane-bound and secreted forms of immunoglobulin μ chain
3. Two mRNAs can be produced from a single immunoglobulin μ gene by alternative RNA processing pathways
4. A single VH gene segment encodes the immune response to phosphorylcholine: Somatic mutation is correlated with the class of the antibody
5. A pseudogene homologous to mouse transplantation antigens: Transplantation antigens are encoded by eight exons that correlate with protein domains
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