New Fluoro Derivatives of the Pyrazolo[5,1-c][1,2,4]benzotriazine 5-Oxide System: Evaluation of Fluorine Binding Properties in the Benzodiazepine Site on γ-Aminobutyrric Acid Type A (GABAA) Receptor. Design, Synthesis, Biological, and Molecular Modeling Investigation-Reference-Cited by-同舟云学术

New Fluoro Derivatives of the Pyrazolo[5,1-c][1,2,4]benzotriazine 5-Oxide System: Evaluation of Fluorine Binding Properties in the Benzodiazepine Site on γ-Aminobutyrric Acid Type A (GABAA) Receptor. Design, Synthesis, Biological, and Molecular Modeling Investigation

Published:2010-10-12 Issue:21 Volume:53 Page:7532-7548
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Guerrini Gabriella¹,Ciciani Giovanna¹,Bruni Fabrizio¹,Selleri Silvia¹,Guarino Chiara¹,Melani Fabrizio²,Montali Marina³,Daniele Simona³,Martini Claudia³,Ghelardini Carla⁴,Norcini Monica⁴,Ciattini Samuele⁵,Costanzo Annarella¹

Affiliation:

1. Dipartimento di Scienze Farmaceutiche, Laboratorio di Progettazione, Sintesi e Studio di Eterocicli Biologicamente Attivi (HeteroBioLab), Università degli Studi di Firenze, Via U. Schiff 6, 50019 Polo Scientifico, Sesto Fiorentino, Firenze, Italy

2. Dipartimento di Scienze Farmaceutiche, Laboratorio di Molecular Modeling, Cheminformatics and QSAR, Università degli Studi di Firenze, Via U. Schiff 6, 50019 Polo Scientifico, Sesto Fiorentino, Firenze, Italy

3. Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Università degli Studi di Pisa, via Bonanno 6, 56126 Pisa, Italy

4. Dipartimento di Farmacologia Preclinica e Clinica Aiazzi-Mancini, Università degli Studi di Firenze, Viale Pieraccini 6, 50139 Firenze, Italy

5. Centro di Crystallografia, Università degli Studi di Firenze, Via della Lastruccia 3, 50019 Polo Scientifico, Sesto Fiorentino, Firenze, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm1001887

Reference44 articles.

1. The complexity of the GABAA receptor shapes unique pharmacological profiles

2. GABAA receptors: Subtypes provide diversity of function and pharmacology

3. GABA-based therapeutic approaches: GABAA receptor subtype functions

4. Synthesis and Study of the Anti-inflammatory Properties of Some Pyrazolo[1,5-a]pyrimidine Derivatives

5. 2-Arylpyrazolo[1,5-a]pyrimidin-3-yl acetamides. New potent and selective peripheral benzodiazepine receptor ligands

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