Discovery of 2-[(2,4-Dichlorophenyl)amino]-N-[(tetrahydro- 2H-pyran-4-yl)methyl]-4-(trifluoromethyl)- 5-pyrimidinecarboxamide, a Selective CB2 Receptor Agonist for the Treatment of Inflammatory Pain-Reference-Cited by-同舟云学术

Discovery of 2-[(2,4-Dichlorophenyl)amino]-N-[(tetrahydro- 2H-pyran-4-yl)methyl]-4-(trifluoromethyl)- 5-pyrimidinecarboxamide, a Selective CB2 Receptor Agonist for the Treatment of Inflammatory Pain

Published:2007-05-01 Issue:11 Volume:50 Page:2597-2600
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Giblin Gerard M. P.¹,O'Shaughnessy Celestine T.¹,Naylor Alan¹,Mitchell William L.¹,Eatherton Andrew J.¹,Slingsby Brian P.¹,Rawlings D. Anthony¹,Goldsmith Paul¹,Brown Andrew J.¹,Haslam Carl P.¹,Clayton Nick M.¹,Wilson Alex W.¹,Chessell Iain P.¹,Wittington Andrew R.¹,Green Richard¹

Affiliation:

1. Neurology and GI Centre of Excellence for Drug Discovery, Molecular Discovery Research, GlaxoSmithKline, New Frontiers Park, Harlow, Essex, CM19 5AW, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm061195%2B

Reference16 articles.

1. CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain

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