Synthesis of Enantiopure trans-3,4-Disubstituted Piperidines. An Enantiodivergent Synthesis of (+)- and (−)-Paroxetine

Author:

Amat Mercedes1,Bosch Joan1,Hidalgo José1,Cantó Margalida1,Pérez Maria1,Llor Núria1,Molins Elies1,Miravitlles Carles1,Orozco Modesto1,Luque Javier1

Affiliation:

1. Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, 08028-Barcelona, Spain; Institut de Ciència de Materials (CSIC), Campus UAB, 08193-Cerdanyola, Spain; Department of Biochemistry and Molecular Biology, Faculty of Chemistry, University of Barcelona, 08028-Barcelona, Spain; and Department of Physical Chemistry, Faculty of Pharmacy, University of Barcelona, 08028-Barcelona, Spain

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Reference33 articles.

1. (b) Fodor, G. B.; Colasanti, B. InAlkaloids:  Chemical andBiological Perspectives; Pelletier, S. W., Ed.; Wiley:  New York, 1985; Vol. 3, Chapter 1, pp 1−90.

2. (c) Strunz, G. M.; Findlay, J. A. InThe Alkaloids; Brossi, A., Ed.; Academic Press:  London, 1985; Vol. 26, Chapter 3, pp 89−183.

3. (d) Angle, R. S.; Breitenbucher, J. G. InStudies in Natural Products Chemistry.Stereoselective Synthesis (Part J); Atta-ur-Rahman, Ed.; Elsevier:  Amsterdam, 1995; Vol. 16, pp 453−502.

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