Streamlined Total Synthesis of Trioxacarcins and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues Thereof. Discovery of Simpler Designed and Potent Trioxacarcin Analogues

Author:

Nicolaou K. C.1ORCID,Chen Pengxi1,Zhu Shugao1,Cai Quan1,Erande Rohan D.1,Li Ruofan1,Sun Hongbao1,Pulukuri Kiran Kumar1,Rigol Stephan1ORCID,Aujay Monette2,Sandoval Joseph2,Gavrilyuk Julia2

Affiliation:

1. Department of Chemistry, BioScience Research Collaborative, Rice University, 6100 Main Street, Houston, Texas 77005, United States

2. AbbVie Stemcentrx, LLC, 450 East Jamie Court, South San Francisco, California 94080, United States

Funder

Welch Foundation

Chongqing University

Cancer Prevention and Research Institute of Texas

China Scholarship Council

Rice University

AbbVie Stemcentrx

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

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