Development of a Scalable Synthesis of a Pyridinyl-3-azabicyclononene, a Novel Nicotinic Partial Agonist-Reference-Cited by-同舟云学术

Development of a Scalable Synthesis of a Pyridinyl-3-azabicyclononene, a Novel Nicotinic Partial Agonist

Published:2013-02-21 Issue:3 Volume:17 Page:413-421
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Breining Scott R.¹,Genus John F.¹,Mitchener J. Pike¹,Cuthbertson Timothy J.¹,Heemstra Ronald¹,Melvin Matt S.¹,Dull Gary M.¹,Yohannes Daniel¹

Affiliation:

1. Formerly, Department of Medicinal Chemistry and ‡Formerly, Department of Chemical Process and Development, Targacept, Inc. 200 East First Street, Suite 300, Winston-Salem, North Carolina 27101, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op400002r

Reference12 articles.

1. Influence of Neuronal Nicotinic Receptors over Nicotine Addiction and Withdrawal

2. Rationale, pharmacology and clinical efficacy of partial agonists of α4β2 nACh receptors for smoking cessation

3. Varenicline Is a Partial Agonist at α4β2 and a Full Agonist at α7 Neuronal Nicotinic Receptors

4. Varenicline Is a Potent Partial Agonist at α6β2* Nicotinic Acetylcholine Receptors in Rat and Monkey Striatum

5. Structure–Activity Studies of 7-Heteroaryl-3-azabicyclo[3.3.1]non-6-enes: A Novel Class of Highly Potent Nicotinic Receptor Ligands

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