Synthesis of Eight Stereoisomers of Pochonicine: Nanomolar Inhibition of β-N-Acetylhexosaminidases

Author:

Zhu Jian-She12,Nakagawa Shinpei3,Chen Wei4,Adachi Isao3,Jia Yue-Mei1,Hu Xiang-Guo1,Fleet George W. J.5,Wilson Francis X.6,Nitoda Teruhiko7,Horne Graeme6,van Well Renate6,Kato Atsushi3,Yu Chu-Yi1

Affiliation:

1. Beijing National Laboratory of Molecular Science (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

2. University of the Chinese Academy of Sciences, Beijing 100049, China

3. Department of Hospital Pharmacy, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan

4. College of Chemistry and Chemical Engineering, Jiang Xi Normal University, Nanchang, Jiangxi 330022, China

5. Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.

6. Summit PLC, 85b Park Drive, Milton Park, Abingdon, Oxon OX14 4RY, U.K.

7. Laboratory of Bioresources Chemistry, the Graduate School of Environmental and Life Science, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

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