Clarification on the Decarboxylation Mechanism in KasA Based on the Protonation State of Key Residues in the Acyl-Enzyme State
Author:
Affiliation:
1. Institut für Physikalische und Theoretische Chemie, Universität Würzburg, Emil-Fischer Strasse 42, 97074, Würzburg, Germany
Publisher
American Chemical Society (ACS)
Subject
Materials Chemistry,Surfaces, Coatings and Films,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/jp403067m
Reference58 articles.
1. WHO | Global TuberculosisControl 2011 http://www.who.int/tb/publications/global_ report/2011/en/(accessed May 27, 2013) .
2. Conditional Depletion of KasA, a Key Enzyme of Mycolic Acid Biosynthesis, Leads to Mycobacterial Cell Lysis
3. Mycolic acid biosynthesis and enzymic characterization of the β-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis
4. Elucidation of the Protonation States of the Catalytic Residues in mtKasA: Implications for Inhibitor Design
5. THE STRUCTURAL BIOLOGY OF TYPE II FATTY ACID BIOSYNTHESIS
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