Optimization of 4-Aminoquinoline/Clotrimazole-Based Hybrid Antimalarials: Further Structure–Activity Relationships, in Vivo Studies, and Preliminary Toxicity Profiling-Reference-Cited by-同舟云学术

Optimization of 4-Aminoquinoline/Clotrimazole-Based Hybrid Antimalarials: Further Structure–Activity Relationships, in Vivo Studies, and Preliminary Toxicity Profiling

Published:2012-07-27 Issue:15 Volume:55 Page:6948-6967
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gemma Sandra¹,Camodeca Caterina¹,Sanna Coccone Salvatore¹,Joshi Bhupendra P.¹,Bernetti Matteo¹,Moretti Vittoria¹,Brogi Simone¹,Bonache de Marcos Maria Cruz¹,Savini Luisa¹,Taramelli Donatella¹²,Basilico Nicoletta¹³,Parapini Silvia¹²,Rottmann Matthias⁴,Brun Reto⁴,Lamponi Stefania¹,Caccia Silvio⁵,Guiso Giovanna⁵,Summers Robert L.⁶,E. Martin Rowena⁶,Saponara Simona⁷,Gorelli Beatrice⁷,Novellino Ettore⁸,Campiani Giuseppe¹,Butini Stefania¹

Affiliation:

1. CIRM Centro Interuniversitario di Ricerche sulla Malaria, Università di Torino, Torino, Italy

2. Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy

3. Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Università degli Studi di Milano, Via Pascal 36, 20133 Milano, Italy;

4. Swiss Tropical and Public Health Institute, Socinstrasse 57, CH-4002 Basel, Switzerland and University of Basel, CH-4003 Basel, Switzerland

5. Istituto di Ricerche Farmacologiche “Mario Negri”, Via la Masa 19, 20156 Milano, Italy

6. Research School of Biology, The Australian National University, Canberra ACT 0200, Australia

7. Dipartimento di Neuroscienze, University of Siena, via A. Moro, 53100, Siena, Italy

8. Dipartimento di Chimica Farmaceutica e Tossicologica, Università di Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300802s

Reference55 articles.

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5. If Artemisinin Drugs Fail, What's Plan B?

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