Structural Basis and SAR for G007-LK, a Lead Stage 1,2,4-Triazole Based Specific Tankyrase 1/2 Inhibitor-Reference-Cited by-同舟云学术

Structural Basis and SAR for G007-LK, a Lead Stage 1,2,4-Triazole Based Specific Tankyrase 1/2 Inhibitor

Published:2013-03-29 Issue:7 Volume:56 Page:3012-3023
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Voronkov Andrew¹,Holsworth Daniel D.¹,Waaler Jo¹,Wilson Steven R.²,Ekblad Bie¹,Perdreau-Dahl Harmonie³,Dinh Huyen¹,Drewes Gerard⁴,Hopf Carsten⁴,Morth Jens P.³⁵,Krauss Stefan¹³

Affiliation:

1. SFI CAST Biomedical Innovation Center, Unit for Cell Signaling, Oslo University Hospital, Forskningsparken, Gaustadalleén 21, 0349, Oslo, Norway

2. Department of Chemistry, University of Oslo, P.O. Box 1033 Blindern, N-0315 Oslo, Norway

3. Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, N-0318 Oslo, Norway

4. Cellzome AG, Meyerhofstrasse 1, 69117 Heidelberg, Germany

5. Institute for Experimental Medical Research, Oslo University Hospital, N-0424 Oslo, Norway

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm4000566

Reference56 articles.

1. Toward a unified nomenclature for mammalian ADP-ribosyltransferases

2. Structural Basis and Sequence Rules for Substrate Recognition by Tankyrase Explain the Basis for Cherubism Disease

3. Tankyrase function at telomeres, spindle poles, and beyond

4. Identification of a Tankyrase-binding Motif Shared by IRAP, TAB182, and Human TRF1 but Not Mouse TRF1

5. The Telomeric Poly(ADP-ribose) Polymerase, Tankyrase 1, Contains Multiple Binding Sites for Telomeric Repeat Binding Factor 1 (TRF1) and a Novel Acceptor, 182-kDa Tankyrase-binding Protein (TAB182)

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