Synthesis and Biological Evaluation of 2-Amino-3-(4-Chlorobenzoyl)-4-[N-(Substituted) Piperazin-1-yl]Thiophenes as Potent Allosteric Enhancers of the A1 Adenosine Receptor-Reference-Cited by-同舟云学术

Synthesis and Biological Evaluation of 2-Amino-3-(4-Chlorobenzoyl)-4-[N-(Substituted) Piperazin-1-yl]Thiophenes as Potent Allosteric Enhancers of the A1 Adenosine Receptor

Published:2008-08-26 Issue:18 Volume:51 Page:5875-5879
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Romagnoli Romeo¹,Baraldi Pier Giovanni¹,Carrion Maria Dora¹,Cara Carlota Lopez¹,Cruz-Lopez Olga¹,Iaconinoto Maria Antonietta¹,Preti Delia¹,Shryock John C.¹,Moorman Allan R.¹,Vincenzi Fabrizio¹,Varani Katia¹,Andrea Borea Pier¹

Affiliation:

1. Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Ferrara, Italy, Department of Medicine, University of Florida, Gainesville, Florida, King Pharmaceuticals Inc., Research and Development, 4000 CentreGreen Way, Suite 300, Cary, North Carolina, Dipartimento di Medicina Clinica e Sperimentale, Sezione di Farmacologia, Università di Ferrara, Ferrara, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm800586p

Reference18 articles.

1. Adenosine, an endogenous distress signal, modulates tissue damage and repair

2. Allosteric Modulation of the Adenosine Family of Receptors

3. Purine and pyrimidine receptors

Cited by 46 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The Chemistry of Aldehydes and Ketones in the Synthesis of Heterocycles - Historical Reactions with a New and Green Perspective;Current Organic Chemistry;2024-07

2. Small molecule allosteric modulation of the adenosine A1 receptor;Frontiers in Endocrinology;2023-06-26

3. Research progress of indole-fused derivatives as allosteric modulators: Opportunities for drug development;Biomedicine & Pharmacotherapy;2023-06

4. Update on the recent development of allosteric modulators for adenosine receptors and their therapeutic applications;Frontiers in Pharmacology;2022-10-05

5. International Union of Basic and Clinical Pharmacology. CXII: Adenosine Receptors: A Further Update;Pharmacological Reviews;2022-03-17