Quantitative Structure−Activity Relationships of 2,4-Diamino-5-(2-X-benzyl)pyrimidines versus Bacterial and Avian Dihydrofolate Reductase-Reference-Cited by-同舟云学术

Quantitative Structure−Activity Relationships of 2,4-Diamino-5-(2-X-benzyl)pyrimidines versus Bacterial and Avian Dihydrofolate Reductase

Published:1998-10-01 Issue:22 Volume:41 Page:4261-4272
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Selassie Cynthia Dias¹,Gan Wei-Xi¹,Kallander Lara S.¹,Klein Teri E.¹

Affiliation:

1. Department of Chemistry, Pomona College, Claremont, California 91711, and Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm970776j

Reference37 articles.

1. Structure-activity relationships of dihydrofolated reductase inhibitors

2. On the structure selectivity problem in drug design. A comparative study of benzylpyrimidine inhibition of vertebrate and bacterial dihydrofolate reductase via molecular graphics and quantitative structure-activity relationships

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