Mechanism and Processing Parameters Affecting the Formation of Methyl Methanesulfonate from Methanol and Methanesulfonic Acid: An Illustrative Example for Sulfonate Ester Impurity Formation

Author:

Teasdale Andrew1,Eyley Stephen C.1,Delaney Ed1,Jacq Karine1,Taylor-Worth Karen1,Lipczynski Andrew1,Reif Van1,Elder David P.1,Facchine Kevin L.1,Golec Simon1,Schulte Oestrich Rolf1,Sandra Pat1,David Frank1

Affiliation:

1. AstraZeneca, R&D Charnwood, Bakewell Road, Loughborough, Leicestershire LE11 5RH, United Kingdom, Reaction Science Consulting, LLC, Suite 202/11 Deer Park Drive, Monmouth Junction, New Jersey 08852, U.S.A., Research Institute for Chromatography, Pres. Kennedypark 26, B-8500, Kortrijk, Belgium, Pfizer Global Research and Development, Analytical R&D, Ramsgate Road, Sandwich, Kent CT13 9NJ, United Kingdom, Schering-Plough, 556 Morris Avenue, Summit, New Jersey 07901-1330, U.S.A.,GlaxoSmithKline, Park Road,...

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference16 articles.

1. Mesylate Ester Type Impurities Contained in Medicinal Products, Swissmedic Department for Control of the Medicinal Products Market, October 23, 2007.

2. Coordination Group for Mutual Recognition-Human committee (CMDh), Request to Assess the Risk of Occurrence of Contamination with Mesilate Esters and Other Related Compounds in Pharmaceutical, EMEA/CMDh/ 98694/2008, London, February 27, 2008.

3. The Correlation of Solvolysis Rates and the Classification of Solvolysis Reactions into Mechanistic Categories

4. REACTIONS OF SULPHONIC ESTERS: I. A KINETIC STUDY OF THE EFFECT OF SUBSTITUENTS FOR A SERIES OF SULPHONIC ESTERS

5. Smith, M. B.; March, J.March’s Advanced Organic Chemistry;Wiley:New York, 2001; p464.

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