Development and Manufacture of the Inosine Monophosphate Dehydrogenase Inhibitor Merimepodib, VX-497-Reference-Cited by-同舟云学术

Development and Manufacture of the Inosine Monophosphate Dehydrogenase Inhibitor Merimepodib, VX-497

Published:2008-07-01 Issue:4 Volume:12 Page:666-673
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Looker Adam R.¹,Littler Benjamin J.¹,Blythe Todd A.¹,Snoonian John R.¹,Ansell Graham K.¹,Jones Andrew D.¹,Nyce Phil¹,Chen Minzhang¹,Neubert Bobbianna J.¹

Affiliation:

1. Chemical Development, Vertex Pharmaceuticals Incorporated, 130 Waverly Street, Cambridge, Massachusetts 02139, U.S.A. and 11010 Torreyana Road, San Diego, California 92121, U.S.A.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op800060h

Reference19 articles.

1. aArmistead, D. M.; Badia, M. C.; Bemis, G. W.; Bethiel, R. S.; Frank, C. A.; Novak, P. M.; Ronkin, S. M.; Saunders, J. O.(Vertex Pharmaceuticals, Inc.). U.S. Patent 6,344,465, 2002; Chem. Abstr.2002,136, 151157.

2. bArmistead, D. M.; Badia, M. C.; Bemis, G. W.; Bethiel, R. S.; Frank, C. A.; Novak, P. M.; Ronkin, S. M.; Saunders, J. O.(Vertex Pharmaceuticals, Inc.). U.S. Patent 6,054,472, 2000; Chem. Abstr.2000,132, 28897.

3. cArmistead, D. M.; Badia, M. C.; Bemis, G. W.; Bethiel, R. S.; Frank, C. A.; Novak, P. M.; Ronkin, S. M.; Saunders, J. O.(Vertex Pharmaceuticals, Inc.). U.S. Patent 5,807,876;Chem. Abstr.2002,136, 151157.

4. VX-497

5. VX-497: A novel, selective IMPDH inhibitor and immunosuppressive agent

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