(Biphenyl-4-yl)methylammonium Chlorides: Potent Anticonvulsants That Modulate Na+ Currents-Reference-Cited by-同舟云学术

(Biphenyl-4-yl)methylammonium Chlorides: Potent Anticonvulsants That Modulate Na+ Currents

Published:2013-07-03 Issue:14 Volume:56 Page:5931-5939
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lee Hyosung¹²,Park Ki Duk¹²,Yang Xiao-Fang¹²,Dustrude Erik T.¹²,Wilson Sarah M.¹²,Khanna Rajesh¹²,Kohn Harold¹²

Affiliation:

1. Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy and ⊥Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599, United States

2. Department of Pharmacology and Toxicology, §Department of Biochemistry and Molecular Biology, and ∥Program in Medical Neuroscience, Paul and Carole Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm4007092

Reference34 articles.

1. Synthesis and Anticonvulsant Activities of N-Benzyl-2-acetamidopropionamide Derivatives

2. Lacosamide

3. The Investigational Anticonvulsant Lacosamide Selectively Enhances Slow Inactivation of Voltage-Gated Sodium Channels

4. Differential Block of Sensory Neuronal Voltage-Gated Sodium Channels by Lacosamide [(2R)-2-(Acetylamino)-N-benzyl-3-methoxypropanamide], Lidocaine, and Carbamazepine

5. Development and Characterization of Novel Derivatives of the Antiepileptic Drug Lacosamide That Exhibit Far Greater Enhancement in Slow Inactivation of Voltage-Gated Sodium Channels

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