1. Department of Chemistry, University of Washington, Seattle, Washington 98195, Institute for Systems Biology, Seattle, Washington 98103, Institute of Molecular Systems Biology, Swiss Federal Institute of Technology (ETH) Zurich, Faculty of Natural Sciences, University of Zurich, CH-8093, Switzerland, Competence Center for Systems Physiology and Metabolic Disease, Zurich, Swizerland, and Department of Pathology, Johns Hopkins University, Baltimore, Maryland 21287