N-Substituted 9β-Methyl-5-(3-hydroxyphenyl)morphans Are Opioid Receptor Pure Antagonists-Reference-Cited by-同舟云学术

N-Substituted 9β-Methyl-5-(3-hydroxyphenyl)morphans Are Opioid Receptor Pure Antagonists

Published:1998-09-16 Issue:21 Volume:41 Page:4143-4149
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Thomas James B.¹,Zheng Xiaoling¹,Mascarella S. Wayne¹,Rothman Richard B.¹,Dersch Christina M.¹,Partilla John S.¹,Flippen-Anderson Judith L.¹,George Clifford F.¹,Cantrell Buddy E.¹,Zimmerman Dennis M.¹,Carroll F. Ivy¹

Affiliation:

1. Chemistry and Life Sciences, Research Triangle Institute, Research Triangle Park, North Carolina 27709, Clinical Psychopharmacology Section, NIDA Addiction Research Section, P.O. Box 5180, Building C, 4980 Eastern Avenue, Baltimore, Maryland 21224, Laboratory for the Structure of Matter, Naval Research Laboratory, Building 35, Room 455, Overlook Avenue, Washington, D.C., 20375, and Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm980290i

Reference22 articles.

1. Selective opioid receptor agonists and antagonists: research tools and potential therapeutic agents

2. Discovery of a Potent, Peripherally Selective trans-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine Opioid Antagonist for the Treatment of Gastrointestinal Motility Disorders

3. New structural concepts for narcotic antagonists defined in a 4-phenylpiperidine series

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