Discovery of a Plasmodium falciparum Glucose-6-phosphate Dehydrogenase 6-phosphogluconolactonase Inhibitor (R,Z)-N-((1-Ethylpyrrolidin-2-yl)methyl)-2-(2-fluorobenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (ML276) That Reduces Parasite Growth in Vitro-Reference-Cited by-同舟云学术

Discovery of a Plasmodium falciparum Glucose-6-phosphate Dehydrogenase 6-phosphogluconolactonase Inhibitor (R,Z)-N-((1-Ethylpyrrolidin-2-yl)methyl)-2-(2-fluorobenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (ML276) That Reduces Parasite Growth in Vitro

Published:2012-08-06 Issue:16 Volume:55 Page:7262-7272
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Preuss Janina¹²³,Maloney Patrick⁴,Peddibhotla Satyamaheshwar⁴,Hedrick Michael P.³,Hershberger Paul⁴,Gosalia Palak³,Milewski Monika³,Li Yujie Linda³,Sugarman Eliot⁴,Hood Becky⁴,Suyama Eigo⁴,Nguyen Kevin⁴,Vasile Stefan⁴,Sergienko Eduard³,Mangravita-Novo Arianna⁴,Vicchiarelli Michael⁴,McAnally Danielle⁴,Smith Layton H.⁴,Roth Gregory P.⁴,Diwan Jena³,Chung Thomas D.Y.³,Jortzik Esther²,Rahlfs Stefan²,Becker Katja²,Pinkerton Anthony B.³,Bode Lars¹

Affiliation:

1. Department of Pediatrics, University of California, San Diego, La Jolla, California 92037, United States

2. Biochemistry and Molecular Biology, Interdisciplinary Research Center, Justus Liebig University, Heinrich-Buff-Ring 26-32, 35392 Giessen, Germany

3. Conrad Prebys Center for Chemical Genomics, Sanford−Burnham Medical Research Institute, La Jolla, California 92037, United States

4. Conrad Prebys Center for Chemical Genomics, Sanford−Burnham Medical Research Institute, Orlando, Florida 32827, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300833h

Reference39 articles.

1. Global malaria mortality between 1980 and 2010: a systematic analysis

2. A Revised Timeline for the Origin of Plasmodium falciparum as a Human Pathogen

3. Plasmodium falciparum Accompanied the Human Expansion out of Africa

4. New hope in the fight against malaria?

5. Vaccines against malaria

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