(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]- pyridin-6-ylphenyl)butanamide: A Selective α-Amino Amide Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes-Reference-Cited by-同舟云学术

(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]- pyridin-6-ylphenyl)butanamide: A Selective α-Amino Amide Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

Published:2006-05-20 Issue:12 Volume:49 Page:3614-3627
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Edmondson Scott D.¹,Mastracchio Anthony¹,Mathvink Robert J.¹,He Jiafang¹,Harper Bart¹,Park You-Jung¹,Beconi Maria¹,Di Salvo Jerry¹,Eiermann George J.¹,He Huaibing¹,Leiting Barbara¹,Leone Joseph F.¹,Levorse Dorothy A.¹,Lyons Kathryn¹,Patel Reshma A.¹,Patel Sangita B.¹,Petrov Aleksandr¹,Scapin Giovanna¹,Shang Jackie¹,Roy Ranabir Sinha¹,Smith Aaron¹,Wu Joseph K.¹,Xu Shiyao¹,Zhu Bing¹,Thornberry Nancy A.¹,Weber Ann E.¹

Affiliation:

1. Merck Research Laboratories, Merck & Co., Inc., Rahway, New Jersey 07065

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm060015t

Reference48 articles.

1. Inhibitors of dipeptidyl peptidase IV: a novel approach for the prevention and treatment of Type 2 diabetes?

2. Inhibitors of proline-specific dipeptidyl peptidases: DPP IV inhibitors as a novel approach for the treatment of Type 2 diabetes

3. Therapeutic Strategies Based on Glucagon-Like Peptide 1

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