Dissociation between the Processivity and Total Activity of γ-Secretase: Implications for the Mechanism of Alzheimer's Disease-Causing Presenilin Mutations
Author:
Affiliation:
1. Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States
Publisher
American Chemical Society (ACS)
Subject
Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/bi2007146
Reference75 articles.
1. Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
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4. The γ-Secretase Complex: Membrane-Embedded Proteolytic Ensemble
5. The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease
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