Anesthetic Potency of Two Novel Synthetic Polyhydric Alkanols Longer than the n-Alkanol Cutoff: Evidence for a Bilayer-Mediated Mechanism of Anesthesia?-Reference-Cited by-同舟云学术

Anesthetic Potency of Two Novel Synthetic Polyhydric Alkanols Longer than the n-Alkanol Cutoff: Evidence for a Bilayer-Mediated Mechanism of Anesthesia?

Published:2005-04-30 Issue:12 Volume:48 Page:4172-4176
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mohr Justin T.¹,Gribble Gordon W.¹,Lin Susan S.¹,Eckenhoff Roderic G.¹,Cantor Robert S.¹

Affiliation:

1. Department of Chemistry, Dartmouth College, Hanover, New Hampshire 03755, Department of Anesthesia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, and MEMPHYSCenter for Biomembrane Physics, Physics Department, University of Southern Denmark, DK-5230 Odense M, Denmark

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm049459k

Reference12 articles.

1. Evidence for a Common Binding Cavity for Three General Anesthetics within the GABAAReceptor

2. Steric Hindrance Is Not Required for n-Alkanol Cutoff in Soluble Proteins

3. Breaking the Meyer-Overton Rule: Predicted Effects of Varying Stiffness and Interfacial Activity on the Intrinsic Potency of Anesthetics

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