Fine-Tuning the Selectivity of Aldosterone Synthase Inhibitors: Structure−Activity and Structure−Selectivity Insights from Studies of Heteroaryl Substituted 1,2,5,6-Tetrahydropyrrolo[3,2,1-ij]quinolin-4-one Derivatives-Reference-Cited by-同舟云学术

Fine-Tuning the Selectivity of Aldosterone Synthase Inhibitors: Structure−Activity and Structure−Selectivity Insights from Studies of Heteroaryl Substituted 1,2,5,6-Tetrahydropyrrolo[3,2,1-ij]quinolin-4-one Derivatives

Published:2011-03-08 Issue:7 Volume:54 Page:2307-2319
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lucas Simon¹,Negri Matthias¹,Heim Ralf¹,Zimmer Christina¹,Hartmann Rolf W.¹²

Affiliation:

1. Pharmaceutical and Medicinal Chemistry, Saarland University, Campus C2.3, D-66123 Saarbrücken, Germany

2. Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Campus C2.3, D-66123 Saarbrücken, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm101470k

Reference75 articles.

1. Aldosterone in Congestive Heart Failure

2. Renin–angiotensin–aldosterone system and myocardial fibrosis

3. Induction of Cardiac Fibrosis by Aldosterone

4. Aldosterone escape during angiotensin-converting enzyme inhibitor therapy in chronic heart failure

5. Aldosterone Escape during Angiotensinconverting Enzyme Inhibitor Therapy in Essential Hypertensive Patients with Left Ventricular Hypertrophy

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