1. For some representative examples on the use of SNAr chemistry over the years for nucleoside modification, please see: (a)Nucleosides andNucleotides; Townsend, L. B., Ed.; Plenum Press: New York, 1988; Vol. 1, Chapter 2, pp. 113−281. (b) Gerster, J. F.; Robins, R. K.J. Am. Chem. Soc.1965,87, 3752−3759. (c) Lakshman, M.; Lehr, R. E.Tetrahedron Lett.1990,31, 1547−1550. (d) Samano, V.; Miles, R. W.; Robins, M. J.J. Am. Chem.Soc.1994,116, 9331−9332. (e) Kim, S. J.; Jajoo, H. K.; Kim, H.Y.; Zhou, L.; Horton, P.; Harris, C. M.; Harris, T. M.Bioorg. Med. Chem.1995,3, 811−822. (f) Chaturvedi, S.; Lakshman, M. K.Carcinogenesis1996,17, 2747−2752. (g) Choi, Y.; George, C.; Strazewski, P.; Marquez, V. E.Org.Lett.2002,4, 589−592. (h) Jeong, L. S.; Jin, D. Z.; Kim, H. O.; Shin, D. H.; Moon, H. R.; Gunaga, P.; Chun, M. W.; Kim, Y.C.; Melman, N.; Gao, Z.G.; Jacobson, K. A.J. Med. Chem.2003,46, 3775−3777.
2. Macro rings. 49. Use of transannular reactions to add bridges to [2.2]paracyclophane