Structure−Activity Relationship of 6-Methylidene Penems Bearing Tricyclic Heterocycles as Broad-Spectrum β-Lactamase Inhibitors: Crystallographic Structures Show Unexpected Binding of 1,4-Thiazepine Intermediates-Reference-Cited by-同舟云学术

Structure−Activity Relationship of 6-Methylidene Penems Bearing Tricyclic Heterocycles as Broad-Spectrum β-Lactamase Inhibitors: Crystallographic Structures Show Unexpected Binding of 1,4-Thiazepine Intermediates

Published:2004-11-18 Issue:26 Volume:47 Page:6556-6568
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Venkatesan Aranapakam M.¹,Gu Yansong¹,Santos Osvaldo Dos¹,Abe Takao¹,Agarwal Atul¹,Yang Youjun¹,Petersen Peter J.¹,Weiss William J.¹,Mansour Tarek S.¹,Nukaga Michiyoshi¹,Hujer Andrea M.¹,Bonomo Robert A.¹,Knox James R.¹

Affiliation:

1. Wyeth Research, 401 N. Middletown Road, Pearl River, New York 10965, Wyeth Lederle Japan, Saitama, Japan, Department of Molecular and Cell Biology, The University of Connecticut, Storrs, Connecticut 06269-3125, and Research Service, Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm049680x

Reference54 articles.

1. beta-lactamase epidemiology and the utility of established and novel beta-lactamase inhibitors

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