Discovery and Preclinical Profiling of 3-[4-(Morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a Highly Potent, Selective, Brain Penetrant, and in Vivo Active LRRK2 Kinase Inhibitor-Reference-Cited by-同舟云学术

Discovery and Preclinical Profiling of 3-[4-(Morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a Highly Potent, Selective, Brain Penetrant, and in Vivo Active LRRK2 Kinase Inhibitor

Published:2014-11-17 Issue:1 Volume:58 Page:419-432
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Henderson Jaclyn L.¹²,Kormos Bethany L.¹²,Hayward Matthew M.¹²,Coffman Karen J.¹²,Jasti Jayasankar¹²,Kurumbail Ravi G.¹²,Wager Travis T.¹²,Verhoest Patrick R.¹²,Noell G. Stephen¹²,Chen Yi¹²,Needle Elie¹²,Berger Zdenek¹²,Steyn Stefanus J.¹²,Houle Christopher¹²,Hirst Warren D.¹²,Galatsis Paul¹²

Affiliation:

1. Worldwide Medicinal Chemistry, ‡Neuroscience Research Unit, and §Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide R&D, 610 Main Street, Cambridge, Massachusetts 02139, United States

2. Worldwide Medicinal Chemistry, ⊥Primary Pharmacology Group, and #Drug Safety R&D, Pfizer Worldwide R&D, Eastern Point Road Groton, Connecticut 06340, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm5014055

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1. CHAPTER 1. Parkinson’s Disease: Symptoms, Unmet Needs and New Therapeutic Targets

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