Neutrophil-Biomimetic “Nanobuffer” for Remodeling the Microenvironment in the Infarct Core and Protecting Neurons in the Penumbra via Neutralization of Detrimental Factors to Treat Ischemic Stroke

Author:

Liu Shanshan12,Xu Jianpei12,Liu Yipu12,You Yang12,Xie Laozhi12,Tong Shiqiang12,Chen Yu12,Liang Kaifan12,Zhou Songlei12,Li Fengan12,Tang Zhuang3,Mei Ni4,Lu Huiping5,Wang Xiaolin3ORCID,Gao Xiaoling6ORCID,Chen Jun12ORCID

Affiliation:

1. School of Pharmacy, Shanghai Pudong Hospital & Department of Pharmaceutics, Fudan University, Lane 826, Zhangheng Road, Shanghai 201203, China

2. Key Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, Lane 826, Zhangheng Road, Shanghai 201203, China

3. School of Pharmacy and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macao 999078, China

4. Shanghai Center for Drug Evaluation and Inspection, Lane 781, Cailun Road, Shanghai 201203, China

5. Department of Pharmacy, Shanghai Pudong Hospital, Fudan University, 2800 Gongwei Road, Shanghai 201399, China

6. Department of Pharmacology and Chemical Biology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Universities Collaborative Innovation Center for Translational Medicine, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China

Funder

National Natural Science Foundation of China

Shanghai Science and Technology Committee

Program of Shanghai Academic/Technology Research Leader

Science and Technology Development Fund of Macau

Publisher

American Chemical Society (ACS)

Subject

General Materials Science

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