Synthesis and Biological Activity of Novel Nonsteroidal Progesterone Receptor Antagonists Based on Cyclocymopol Monomethyl Ether-Reference-Cited by-同舟云学术

Synthesis and Biological Activity of Novel Nonsteroidal Progesterone Receptor Antagonists Based on Cyclocymopol Monomethyl Ether

Published:1996-01-01 Issue:9 Volume:39 Page:1778-1789
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hamann Lawrence G.¹,Farmer Luc J.¹,Johnson Michael G.¹,Bender Steven L.¹,Mais Dale E.¹,Wang Ming-Wei¹,Crombie Diane¹,Goldman Mark E.¹,Jones Todd K.¹

Affiliation:

1. Departments of Endocrine Chemistry Research, Endocrine Research, and New Leads Discovery, Ligand Pharmaceuticals, Inc., 9393 Towne Centre Drive, San Diego, California 92121

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm950747d

Reference58 articles.

1. Treatment of breast cancer with different antiprogestins: Preclinical and clinical studies

2. Endocrine responses to long-term administration of the antiprogesterone RU486 in patients with pelvic endometriosis*†*Presented in part at the 46th Annual Meeting of The American Fertility Society, Washington, D.C., October 15 to 18, 1990.†Supported by Roussel-Uclaf, Romainville, France.

3. Mifepristone (RU 486) treatment of meningiomas.

4. Daily administration of the progesterone antagonist RU 486 prevents implantation in the cycling guinea pig

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