Cystic Fibrosis Transmembrane Conductance Regulator: Using Differential Reactivity toward Channel-Permeant and Channel-Impermeant Thiol-Reactive Probes To Test a Molecular Model for the Pore-Reference-Cited by-同舟云学术

Cystic Fibrosis Transmembrane Conductance Regulator: Using Differential Reactivity toward Channel-Permeant and Channel-Impermeant Thiol-Reactive Probes To Test a Molecular Model for the Pore

Published:2009-09-29 Issue:42 Volume:48 Page:10078-10088
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Alexander Christopher¹,Ivetac Anthony²,Liu Xuehong¹,Norimatsu Yohei¹,Serrano Jose R.¹,Landstrom Allison¹,Sansom Mark²,Dawson David C.¹

Affiliation:

1. Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239

2. Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K.

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi901314c

Reference54 articles.

1. Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function

2. Atomic model of human cystic fibrosis transmembrane conductance regulator: Membrane-spanning domains and coupling interfaces

3. Evolutionary and functional divergence between the cystic fibrosis transmembrane conductance regulator and related ATP-binding cassette transporters

4. The ABC protein turned chloride channel whose failure causes cystic fibrosis

5. Identification of cystic fibrosis transmembrane conductance regulator channel-lining residues in and flanking the M6 membrane-spanning segment

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