1. Department of Biochemistry (Signal Transduction Research Group), University of Alberta, Edmonton, Alberta T6G 2S2, Canada, Centre de Recherche en Rhumatologie et Immunologie, Centre de Recherche du CHUQ, Laval University, Ste-Foy, Québec G1V 4G2, Canada, and Department of Pharmacological Sciences and Institute for Cell and Developmental Biology, Stony Brook Health Science Center, Stony Brook, New York 11794-8651