Identification of N-(5-tert-Butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea Dihydrochloride (AC220), a Uniquely Potent, Selective, and Efficacious FMS-Like Tyrosine Kinase-3 (FLT3) Inhibitor-Reference-Cited by-同舟云学术

Identification of N-(5-tert-Butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea Dihydrochloride (AC220), a Uniquely Potent, Selective, and Efficacious FMS-Like Tyrosine Kinase-3 (FLT3) Inhibitor

Published:2009-09-16 Issue:23 Volume:52 Page:7808-7816
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chao Qi¹,Sprankle Kelly G.¹,Grotzfeld Robert M.¹,Lai Andiliy G.¹,Carter Todd A.¹,Velasco Anne Marie¹,Gunawardane Ruwanthi N.¹,Cramer Merryl D.¹,Gardner Michael F.¹,James Joyce¹,Zarrinkar Patrick P.¹,Patel Hitesh K.¹,Bhagwat Shripad S.¹

Affiliation:

1. Ambit Biosciences, 4215 Sorrento Valley Boulevard, San Diego, California 92121

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9007533

Reference21 articles.

1. The roles of FLT3 in hematopoiesis and leukemia

2. Targeting FLT3 Kinase in Acute Myelogenous Leukemia: Progress, Perils, and Prospects

3. FLT3 Tyrosine Kinase Inhibitors

4. Flt3 Receptor Tyrosine Kinase as a Drug Target in Leukemia

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