β-Lactamase Inhibition by 7-Alkylidenecephalosporin Sulfones: Allylic Transposition and Formation of an Unprecedented Stabilized Acyl-Enzyme

Author:

Rodkey Elizabeth A.1,McLeod David C.2,Bethel Christopher R.3,Smith Kerri M.4,Xu Yan4,Chai Weirui2,Che Tao1,Carey Paul R.1,Bonomo Robert A.3,van den Akker Focco1,Buynak John D.25

Affiliation:

1. Department of Biochemistry, Case Western Reserve University, 10900 Euclid Ave., Cleveland, Ohio 44106, United States

2. Department of Chemistry, Southern Methodist University, 3215 Daniel Ave., Dallas, Texas 75275, United States

3. Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, 10701 East Boulevard, Cleveland, Ohio 44106, United States and Departments of Medicine, Pharmacology, Molecular Biology and Microbiology, Case Western Reserve University, 10900 Euclid Ave., Cleveland, Ohio 44106, United States

4. Department of Chemistry, Cleveland State University, 2121 Euclid Ave., Cleveland, Ohio 44115, United States

5. Center for Drug Discovery, Design, and Development, Southern Methodist University, Dallas, Texas 75275, United States

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

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