Design and Synthesis of (+)-Discodermolide–Paclitaxel Hybrids Leading to Enhanced Biological Activity-Reference-Cited by-同舟云学术

Design and Synthesis of (+)-Discodermolide–Paclitaxel Hybrids Leading to Enhanced Biological Activity

Published:2011-08-26 Issue:18 Volume:54 Page:6319-6327
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Smith Amos B.¹,Sugasawa Keizo¹²,Atasoylu Onur¹,Yang Chia-Ping Huang³,Horwitz Susan Band³

Affiliation:

1. Department of Chemistry, Monell Chemical Senses Center and Laboratory for Research on the Structure of Matter, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States

2. Astellas Pharma Inc., Tsukuba-shi, Ibaraki 305-8585, Japan

3. Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm200692n

Reference75 articles.

1. Discodermolide: a new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta

2. Total synthesis of the immunosuppressive agent (-)-discodermolide

3. Distinct binding and cellular properties of synthetic (+)- and (-)-discodermolides

4. DISCODERMOLIDE—A NEW, MARINE-DERIVED IMMUNOSUPPRESSIVE COMPOUND

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