Shedding of Soluble Epidermal Growth Factor Receptor (sEGFR) Is Mediated by a Metalloprotease/Fibronectin/Integrin Axis and Inhibited by Cetuximab

Author:

Wilken Jason A.1,Perez-Torres Marianela2,Nieves-Alicea Rene3,Cora Elsa M.3,Christensen Trace A.4,Baron Andre T.5,Maihle Nita J.16

Affiliation:

1. Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, P.O. Box 208063, 310 Cedar Street, FMB 211, New Haven, Connecticut 06520-8063, United States

2. Department of Pharmaceutical Sciences, University of Puerto Rico, School of Pharmacy, P.O. Box 365067, San Juan, Puerto Rico, 00936

3. Department of Biochemistry, University of Puerto Rico, Medical Sciences Campus, P.O. Box 365067, San Juan, Puerto Rico, 00936

4. Department of Biochemistry and Molecular Biology, Mayo Clinic Foundation, Room 1421 Guggenheim Building, 200 First Street SW, Rochester, Minnesota 55905, United States

5. Department of Epidemiology, College of Public Health and the Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Kentucky, 111 Washington Avenue, Lexington, Kentucky 40356, United States

6. Departments of Pathology and Pharmacology, Yale School of Medicine, P.O. Box 208063, 310 Cedar Street, FMB 210, New Haven, Connecticut 06520-8063, United States

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

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