Nucleophilic Reactions between Thiols and a Tobacco Specific Nitrosamine Metabolite, 4-Hydroxy-1-(3-pyridyl)-1-butanone
Author:
Affiliation:
1. Division of Environmental and Occupational Health and Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455
Publisher
American Chemical Society (ACS)
Subject
Toxicology,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/tx025676h
Reference15 articles.
1. Hecht, S. S., Spratt, T. E., and Trushin, N. (1988) Evidence for 4-(3-pyridyl)-4-oxobutylation of DNA in F344 rats treated with the tobacco specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone andN‘-nitrosonornicotine.Carcinogenesis9, 161−165.
2. Spratt, T. E., Peterson, L. A., Confer, W. L., and Hecht, S. S. (1990) Solvolysis of model compounds for α-hydroxylation ofN‘-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: Evidence for a cyclic oxonium ion intermediate in the alkylation of nucleophiles.Chem. Res. Toxicol.3, 350−356.
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