Is It Essential to Use Anhydrous Acetonitrile in the Manufacture of Phosphorothioate Oligonucleotides?
Author:
Affiliation:
1. Isis Pharmaceuticals, 2292 Faraday Avenue, Carlsbad, California 92008, U.S.A.
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/op9900333
Reference17 articles.
1. Crooke, S. T.Antisense Therapeutics in Biotechnology & GeneticEngineering Reviews; Intercept Ltd. Hampshire, UK, 1998; pp 121−157.
2. Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo
3. Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase
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