USP7-Based Deubiquitinase-Targeting Chimeras Stabilize AMPK

Author:

Liu Jing12,Hu Xiaoping3,Luo Kaixiu3,Xiong Yan3,Chen Li1,Wang Zhen1,Inuzuka Hiroyuki1,Qian Chao3,Yu Xufen3ORCID,Xie Ling4,Muneer Adil4ORCID,Zhang Dingpeng5,Paulo Joao A.6,Chen Xian4,Jin Jian3ORCID,Wei Wenyi1ORCID

Affiliation:

1. Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, United States

2. Department of Urology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

3. Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences, Oncological Sciences and Neuroscience, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States

4. Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

5. Department of Cancer Biology, Dana-Farber Cancer Institute; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02215, United States

6. Department of Cell Biology, Blavatnik Institute at Harvard Medical School, Boston, Massachusetts 02115, United States

Funder

National Cancer Institute

National Institute of Diabetes and Digestive and Kidney Diseases

Icahn School of Medicine at Mount Sinai

National Institute on Aging

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

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