Ligand–Receptor Interaction-Induced Intracellular Phase Separation: A Global Disruption Strategy for Resistance-Free Lethality of Pathogenic Bacteria

Author:

Yang Anming1,Song Junfeng1,Li Jiaqi1,Li Youzhi1,Bai Silei1,Zhou Cailing1,Wang Min1,Zhou Yu1,Wen Kang1,Luo Miaomiao1,Chen Peiren1,Liu Bo2ORCID,Yang Huan3,Bai Yugang1ORCID,Wong Wing-Leung4ORCID,Cai Qingyun1,Pu Huangsheng56,Qian Yu7ORCID,Hu Wenhao7ORCID,Huang Wei2ORCID,Wan Muyang8,Zhang Chunhui8,Feng Xinxin1ORCID

Affiliation:

1. State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, and School of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan 410082, China

2. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No.555 Zuchongzhi Rd, Pudong, Shanghai 201203, China

3. School of Medical Technology, Xuzhou Medical University, Xuzhou 221004, China

4. State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR 999077, China

5. College of Advanced Interdisciplinary Studies & Hunan Provincial Key Laboratory of Novel NanoOptoelectronic Information Materials and Devices, National University of Defense Technology, Changsha, Hunan 410073, China

6. Nanhu Laser Laboratory, National University of Defense Technology, Changsha 410073, China

7. State Key Laboratory of Anti-Infective Drug Discovery and Development, Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China

8. College of Biology, Hunan University, Changsha, Hunan 410082, China

Funder

National University of Defense Technology

Health and Medical Research Fund

Natural Science Foundation of Hunan Province

National Key Research and Development Program of China

Hunan University

National Natural Science Foundation of China

Natural Science Foundation of Changsha

Publisher

American Chemical Society (ACS)

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