The Dual Mode of Antibacterial Action of the Synthetic Small Molecule DCAP Involves Lipid II Binding

Author:

Ludwig Kevin C.12ORCID,Puls Jan-Samuel1ORCID,Matos de Opitz Cruz L.3ORCID,Innocenti Paolo4,Daniel Jan-Martin12,Bornikoel Jan3,Arts Melina1ORCID,Krannich Sebastian1,Straetener Jan3,Brajtenbach Dominik5,Henrichfreise Beate1,Sass Peter36ORCID,Mueller Anna1,Martin Nathaniel I.4ORCID,Brötz-Oesterhelt Heike367ORCID,Kubitscheck Ulrich5,Grein Fabian12,Schneider Tanja12ORCID

Affiliation:

1. Institute for Pharmaceutical Microbiology, University of Bonn, University Hospital Bonn, Meckenheimer Allee 168, 53115 Bonn, Germany

2. German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, 53115 Bonn, Germany

3. Department of Microbial Bioactive Compounds, Interfaculty Institute of Microbiology & Infection Medicine, University of Tübingen, Auf der Morgenstelle 28, 72076 Tübingen, Germany

4. Biological Chemistry Group, Institute of Biology Leiden, Leiden University, Sylviusweg 72, 2333 BE Leiden, the Netherlands

5. Clausius-Institute for Physical and Theoretical Chemistry, University of Bonn, Wegelerstraße 12, 53115 Bonn, Germany

6. German Center for Infection Research (DZIF), Partner Site Tübingen, 72076 Tübingen, Germany

7. Cluster of Excellence “Controlling Microbes to Fight Infections”, University of Tübingen, 72076 Tübingen, Germany

Funder

Deutsche Forschungsgemeinschaft

Deutsches Zentrum f?r Infektionsforschung

Publisher

American Chemical Society (ACS)

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