Identification of 4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a Novel Inhibitor of AKT Kinase-Reference-Cited by-同舟云学术

Identification of 4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a Novel Inhibitor of AKT Kinase

Published:2008-08-23 Issue:18 Volume:51 Page:5663-5679
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Heerding Dirk A.¹,Rhodes Nelson¹,Leber Jack D.¹,Clark Tammy J.¹,Keenan Richard M.¹,Lafrance Louis V.¹,Li Mei¹,Safonov Igor G.¹,Takata Dennis T.¹,Venslavsky Joseph W.¹,Yamashita Dennis S.¹,Choudhry Anthony E.¹,Copeland Robert A.¹,Lai Zhihong¹,Schaber Michael D.¹,Tummino Peter J.¹,Strum Susan L.¹,Wood Edgar R.¹,Duckett Derek R.¹,Eberwein Derek¹,Knick Victoria B.¹,Lansing Timothy J.¹,McConnell Randy T.¹,Zhang ShuYun¹,Minthorn Elisabeth A.¹,Concha Nestor O.¹,Warren Gregory L.¹,Kumar Rakesh¹

Affiliation:

1. Oncology Center of Excellence for Drug Discovery, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm8004527

Reference34 articles.

1. Activation of AKT Kinases in Cancer: Implications for Therapeutic Targeting

2. The Akt/PKB Family of Protein Kinases: A Review of Small Molecule Inhibitors and Progress Towards Target Validation

3. Perturbations of the AKT signaling pathway in human cancer

4. The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer

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