Discovery of Novel PI3-Kinase δ Specific Inhibitors for the Treatment of Rheumatoid Arthritis: Taming CYP3A4 Time-Dependent Inhibition-Reference-Cited by-同舟云学术

Discovery of Novel PI3-Kinase δ Specific Inhibitors for the Treatment of Rheumatoid Arthritis: Taming CYP3A4 Time-Dependent Inhibition

Published:2012-06-11 Issue:12 Volume:55 Page:5887-5900
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Safina Brian S.¹,Baker Stewart²,Baumgardner Matt¹,Blaney Paul M.³,Chan Bryan K.¹,Chen Yung-Hsiang¹,Cartwright Matthew W.³,Castanedo Georgette¹,Chabot Christine¹,Cheguillaume Arnaud J.³,Goldsmith Paul²,Goldstein David M.⁴,Goyal Bindu⁴,Hancox Timothy²,Handa Raj K.³,Iyer Pravin S⁴,Kaur Jasmit²,Kondru Rama⁴,Kenny Jane R.¹,Krintel Sussie L.³,Li Jun¹,Lesnick John¹,Lucas Matthew C.⁴,Lewis Cristina¹,Mukadam Sophie¹,Murray Jeremy¹,Nadin Alan J.³,Nonomiya Jim¹,Padilla Fernando⁴,Palmer Wylie S.⁴,Pang Jodie¹,Pegg Neil²,Price Steve³,Reif Karin¹,Salphati Laurent¹,Savy Pascal A.³,Seward Eileen M.³,Shuttleworth Stephen²,Sohal Sukhjit²,Sweeney Zachary K.¹,Tay Suzanne¹,Tivitmahaisoon Parcharee⁴,Waszkowycz Bohdan³,Wei Binqing¹,Yue Qin¹,Zhang Chenghong¹,Sutherlin Daniel P.¹

Affiliation:

1. Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States

2. Piramed Pharma, 957 Buckingham Avenue, Slough, Berks SL1 4NL, United Kingdom

3. Argenta Discovery, 8/9 Spire Green Centre, Flex Meadow, Harlow CM19 5TR, United Kingdom

4. Roche Research Center, 340 Kingsland Street, Nutley, New Jersey 07110, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm3003747

Reference39 articles.