Discovery of a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR)-Reference-Cited by-同舟云学术

Discovery of a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR)

Published:2013-03-07 Issue:6 Volume:56 Page:2218-2234
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Takeuchi Craig S.¹,Kim Byung Gyu¹,Blazey Charles M.¹,Ma Sunghoon¹,Johnson Henry W. B.¹,Anand Neel K.¹,Arcalas Arlyn¹,Baik Tae Gon¹,Buhr Chris A.¹,Cannoy Jonah¹,Epshteyn Sergey¹,Joshi Anagha¹,Lara Katherine¹,Lee Matthew S.¹,Wang Longcheng¹,Leahy James W.¹,Nuss John M.¹,Aay Naing¹,Aoyama Ron¹,Foster Paul¹,Lee Jae¹,Lehoux Isabelle¹,Munagala Narsimha¹,Plonowski Arthur¹,Rajan Sharmila¹,Woolfrey John¹,Yamaguchi Kyoko¹,Lamb Peter¹,Miller Nicole¹

Affiliation:

1. Department of Drug Discovery, Exelixis, 169 Harbor Way, South San Francisco, California 94083, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm3007933

Reference37 articles.

1. The tor pathway: a target for cancer therapy

2. Defining the Role of mTOR in Cancer

3. Dysregulation of the TSC-mTOR pathway in human disease

4. Rapamycin-insensitive Regulation of 4E-BP1 in Regenerating Rat Liver

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