Side Chain Methyl Substitution in the δ-Opioid Receptor Antagonist TIPP Has an Important Effect on the Activity Profile-Reference-Cited by-同舟云学术

Side Chain Methyl Substitution in the δ-Opioid Receptor Antagonist TIPP Has an Important Effect on the Activity Profile

Published:1998-12-01 Issue:26 Volume:41 Page:5167-5176
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tourwé Dirk¹,Mannekens Els¹,Diem Trang Nguyen Thi¹,Verheyden Patricia¹,Jaspers Hendrika¹,Tóth Géza¹,Péter Antal¹,Kertész István¹,Török Gabriella¹,Chung Nga N.¹,Schiller Peter W.¹

Affiliation:

1. Eenheid Organische Chemie, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium, Isotope Laboratory, Biological Research Center, Hungarian Academy of Sciences, P.O. Box 521, H-6701 Szeged, Hungary, Department of Inorganic and Analytical Chemistry, Attila József University, P.O. Box 440, H-6701 Szeged, Hungary, Laboratory of Chemical Biology and Peptide Research, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W1R7

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm981011u

Reference59 articles.

1. Differential stereochemical requirements of mu vs. delta opioid receptors for ligand binding and signal transduction: development of a class of potent and highly delta-selective peptide antagonists.

2. Pharmacophore elements of the TIPP class of delta opioid receptor antagonists

3. Schiller, P. W.; Weltrowska, G.; Nguyen, T. M.D.; Lemieux, C.; Chung, N. N.; Zelent, B.; Wilkes, B. C.; Carpenter, K. A. Structure-agonist/antagonist activity relationships of TIPP analogs. InPeptides:Chemistry, Structureand Biology, Kaumaya, P. T. P., Hodges, R. S., Eds., Mayflower: Kingswinford, England, 1996; pp 609−611.

4. Selective Opioid Dipeptides

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